It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
not to dispute the whole tapering thing but after forty days on t3 your thyroid will be shut down and will continue to be as long as your on even while your tapering down. so to remain shut down while using less t3 will mean diminished returns and wont help recovery since you wont recover till your off the t3.
anyhow if you like shoot me a pm and ill give you links to other sites with t3 profiles and dosage recommendations.
as for the clen it is the one you should be careful with and more is not can use it the entire forty days provided you use ketotifen or benadryl. i personally go with benadryl and it works just fine and is cheaper to.