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Acute effects may include anxiety and panic, impaired attention, and memory (while intoxicated), an increased risk of psychotic symptoms, and possibly an increased risk of accidents if a person drives a motor vehicle while intoxicated. [72] Short-term cannabis intoxication can hinder the mental processes of organizing and collecting thoughts. This condition is known as temporal disintegration. [73] Psychotic episodes are well-documented and typically resolve within minutes or hours. There have been few reports of symptoms lasting longer. [74] [75] Studies have found that cannabis use during adolescence is associated with impairments in memory that persist beyond short-term intoxication. [76]

More specifically, the biosynthesis of (−)-menthol takes place in the secretory gland cells of the peppermint plant. Geranyl diphosphate synthase (GPPS), first catalyzes the reaction of IPP and DMAPP into geranyl diphosphate . Next (−)-limonene synthase (LS) catalyzes the cyclization of geranyl diphosphate to (−)- limonene . (−)-Limonene-3-hydroxylase (L3OH), using O 2 and NADPH , then catalyzes the allylic hydroxylation of (−)-limonene at the 3 position to (−)-trans-isopiperitenol. (−)- trans -Isopiperitenol dehydrogenase (iPD) further oxidizes the hydroxyl group on the 3 position using NAD + to make (−)-isopiperitenone. (−)-Isopiperitenone reductase (iPR) then reduces the double bond between carbons 1 and 2 using NADPH to form (+)- cis -isopulegone. (+)- cis -Isopulegone isomerase (iPI) then isomerizes the remaining double bond to form (+)-pulegone. (+)-Pulegone reductase (PR) then reduces this double bond using NADPH to form (−)-menthone. (−)-Menthone reductase (MR) then reduces the carbonyl group using NADPH to form (−)-menthol. [9]

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